A recent study reveals that individuals who come off new GLP-1 drugs like Mounjaro or Wegovy can put back on shed pounds at a significantly accelerated pace than those who end traditional diet and exercise plans.
Published data in a major health publication points out that while overweight people frequently drop substantial amounts of their body weight while undergoing treatment, the mass is regained at an estimated rate of nearly a kilo each month after stopping.
"People purchasing such treatments should be aware of the risk of quick rebound weight gain when the therapy is stopped," cautioned researcher Dr. Susan Jebb.
This pace of regain means a reversion to pre-treatment mass within about 18 months.
Weighing Treatments
The study, which looked at dozens of trials involving over 9,000 of participants, compared the results of the injectable medications with other pills.
The team emphasize that individuals who lose weight through lifestyle changes alone generally have a slower weight regain—perhaps 100 grams monthly—post-intervention.
Understanding the Rapid Regain
Nutrition scientists propose the mechanism of the jabs accounts for the accelerated regain.
These medications imitate a body's own chemical called GLP-1, which controls appetite.
"Long-term administration of the hormone levels far above than the body's typical production may cause the body to produce less of its endogenous hormone, and could lessen sensitivity to its effects," explained Dr. Adam Collins, a nutrition expert.
"Stopping of this hormone supplement means hunger is uncontrolled, making binge eating a significant risk."
A Chronic Condition?
The NHS suggest the jabs for people with weight-linked health risks, accompanied by recommended lifestyle changes.
Many experts argue that, due to the high risk of weight regain, the treatment might need to be ongoing.
This opinion is supported by drug manufacturers, who state that the findings "highlight the long-term nature of excess weight," akin to managing diseases like high blood pressure.
Patient Accounts
People who have come off the medication report a powerful resurgence of cravings.
"It felt as if something flipping and you become starving," said an individual.
The struggle is worsened if users have not adopted sustainable dietary or behavioural changes during therapy.
Widespread Interest
Survey data suggest that a significant number of people in the UK have used these injections in the past year, with interest remaining high.
- Adoption is greater among women compared to men.
- The middle-aged age group shows the highest level of interest.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
In conclusion, researchers caution that while GLP-1 drugs are effective agents for shedding pounds, they are not a permanent cure and lasting health benefits likely depends on integrated lifestyle management.
